dienestrol

Ligand id: 7160

Name: dienestrol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 40.46
Molecular weight 266.13
XLogP 6.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a topical application to treat atrophic vaginitis and vulvar atrophy. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Dienestrol is a synthetic, non-steroidal estrogen and is therefore an agonist of the estrogen receptor. Although local action of this hormone analogue improves the symptoms of the indicated conditions, its precise mechanism of action is unclear. See the DrugBank link for further details.