diethylpropion

Ligand id: 7161

Name: diethylpropion

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 20.31
Molecular weight 205.15
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is used to treat obesity, in combination with diet and exercise.
Mechanism Of Action and Pharmacodynamic Effects
As an amphetamine type drug, diethylpropion (or rather its active metabolite, ethcathinone) causes an increase in neuronal catecholamine levels by reducing their re-uptake by inhibiting activity of the dopamine and norepinephrine transporters (SLC6A3 and SLC6A2 respectively). Increasing catecholamine signalling suppresses CNS hunger signals and appetite. Amphetamines may also modulate leptin and neuropeptide Y levels, two peptides which affect feelings of satiety, eating behaviour, energy expenditure and fat storage.