disopyramide

Ligand id: 7167

Name: disopyramide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 60.21
Molecular weight 339.23
XLogP 6.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat cardiac arrhythmias.
Mechanism Of Action and Pharmacodynamic Effects
This drug stabilises the cardiac membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. CHEMBL report that this drug acts by blocking sodium channel α subunits (genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section).
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