doxapram

Ligand id: 7169

Name: doxapram

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 32.78
Molecular weight 378.23
XLogP 6.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Doxapram is used as a ventilatory stimulant in patients experiencing respiratory failure, or following anaestheia.
Mechanism Of Action and Pharmacodynamic Effects
The molecular targets of this drug are listed by ChEMBL as the potassium channel subfamily K members 3 and 9 (KCNK3 and KCNK9). Inhibition of these proteins in the carotid body (a small cluster of cells on the carotid artery whose chemoreceptors sense and respond to the partial pressure of oxygen, CO2, pH and temperature of arterial blood) is believed to cause respiratory stimulation. See the DrugBank link for further details.
External links