droperidol

Ligand id: 7172

Name: droperidol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 58.36
Molecular weight 379.17
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Droperidol is used as a sedative prior to surgical procedures and as an antiemetic.
Mechanism Of Action and Pharmacodynamic Effects
The major actions of this drug appear to be via antagonism of central dopamine (DRD2, DRD3, DRD4) and serotonin 5-HT2a (HTR2A) receptors. See the DrugBank link for further details. However, we have been unable to find affinity data for this drug at any of its proposed targets, to substantiate its MMOA.
External links