dyclonine

Ligand id: 7173

Name: dyclonine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 29.54
Molecular weight 289.2
XLogP 3.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dyclonine is the active ingredient in lozenges and throat sprays used to treat minor pain in the mouth and throat (eg Sucrets® and Cepacol®)
Mechanism Of Action and Pharmacodynamic Effects
This drug stabilises the neuronal membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. ChEMBL report that this drug acts by blocking sodium channel α subunits. The genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section.