Ligand id: 7176

Name: epinastine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: epinastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 39.12
Molecular weight 249.13
XLogP 5.77
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Epinastine is used in eye drops to treat the itching associated with allergic conjunctivitis.
Mechanism Of Action and Pharmacodynamic Effects
Epinastine blocks the action of endogenous histamine at the histamine H1 receptor. It stabilises mast cells and prevents release of proinflammatory mediators.
External links