Ligand id: 7178

Name: esmolol

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View more information in the IUPHAR Pharmacology Education Project: esmolol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 67.79
Molecular weight 295.18
XLogP 2.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Esmolol is indicated for the treatment of acute supraventricular tachycardia, atrial fibrillation or atrial flutter.
Mechanism Of Action and Pharmacodynamic Effects
Esmolol anatgonises β1-adrenoceptors in the sympathetic system. This prevents the receptors from processing signals from endogenous epinephrine and norepinephrine resulting in decreased force of heart contractions and lowered heart rate. See the DrugBank link for further details.
External links