ethacrynic acid

Ligand id: 7179

Name: ethacrynic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 63.6
Molecular weight 302.01
XLogP 2.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Ethacrynic acid is used to reduce oedema associated with conditions such as congestive heart failure, liver disease or nephrotic syndrome.
Mechanism Of Action and Pharmacodynamic Effects
Ethacrynic acid inhibits ion transport via the kidney-specific Na-K-Cl symporter (SLC12A1). These transporters are located in the ascending loop of Henle and their inhibition results in increased water excretion.
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