ethchlorvynol

Ligand id: 7180

Name: ethchlorvynol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 144.03
XLogP 1.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Ethchlorvynol is used to treat insomnia. Although no longer available in the US, this drug may still be available elsewhere.
Mechanism Of Action and Pharmacodynamic Effects
Ethchlorvynol is a positive modulator of the GABAA anion channel. The drug thereby increases inhibitory GABAergic tone and causes neuro-inhibition of the cortical and limbic systems, observed clinically as a sedative-hypnotic effect.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.