etidronic acid

Ligand id: 7184

Name: etidronic acid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 5
Rotatable bonds 2
Topological polar surface area 154.91
Molecular weight 205.97
XLogP -3.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bisphosphonates are used to treat and prevent disorders such as hypercalcaemia, osteoporosis and Paget’s disease, and bone disorders and tissue calcification in cancer patients. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
By shifting the equilibrium of bone resorption/formation towards the formation side by various potential mechanisms, drug treatment makes bone stronger. This drug may also cause apoptosis of osteclasts (bone resorbing cells) by antagonising ATP in energy metabolism which ties with ChEMBL listing the target of this drug as ATP. See the DrugBank link for further details.
As the precise mechanism of action of this drug is not fully resolved, we have not tagged a primary drug-target interaction.