flavoxate

Ligand id: 7187

Name: flavoxate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 55.84
Molecular weight 391.18
XLogP 5.67
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flavoxate is used to treat bladder symptoms including frequent or urgent urination, increased nocturnal urination, bladder pain, and urinary incontinence. Such symptoms may be caused by an overactive bladder, prostate enlargement, bladder infection or urethral irritation. This drug may also be used prior to catheterisation and cystoscopic procedures.
Mechanism Of Action and Pharmacodynamic Effects
Flavoxate acts as a parasympatholytic, reducing contractions in the smooth muscle of the bladder and urinary tract, likely through antagonism of muscarinic acetylcholine receptors. See the DrugBank link for fruther details. ChEMBL list the targets of this drug as phosphodiesterase isoforms, PDE4, 7 and 8.
External links