flurazepam

Ligand id: 7188

Name: flurazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 35.91
Molecular weight 387.15
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flurazepam is used to treat insomnia.
Mechanism Of Action and Pharmacodynamic Effects
Flurazepam binds to the benzodiazepine (BZD) binding sites on GABAA receptor complexes in the central nervous system. This acts to increase binding of inhibitory GABA at these sites and results in overall neuro-inhibition and this is responsible for the drug's sedative action.
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