Ligand id: 7190

Name: fosphenytoin

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View more information in the IUPHAR Pharmacology Education Project: fosphenytoin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 129.47
Molecular weight 362.07
XLogP 3.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fosphenytoin is used to treat grand mal seizures and seizures associated with brain trauma (surgical or accidental).
Mechanism Of Action and Pharmacodynamic Effects
This drug blocks sodium channel α subunits (genes SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section). This appears to reduce seizure propagation and limit the spread of seizure activity in the brain. See the DrugBank link for further details.
External links