guanadrel

Ligand id: 7193

Name: guanadrel

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 80.36
Molecular weight 213.15
XLogP 1.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Guanadrel is a substrate of the norepinephrine transporter SLC6A2. The drug is transported into storage granules in sympathetic neurones in place of endogenous ligand, and thereby decreases norepinephrine available for release across the synapse. This action reduces neurotransmitter release, subsequent postganglionic adrenoceptor activation and ultimately reduces arteriolar vasoconstriction.
External links