guanethidine

Ligand id: 7194

Name: guanethidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 65.14
Molecular weight 198.18
XLogP 1.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Guanethidine is a substrate of the norepinephrine transporter, NET (SLC6A2). The drug is transported into storage granules in sympathetic neurones in place of endogenous ligand, and thereby decreases teh quantity of norepinephrine available for release across the synapse. This action reduces neurotransmitter release, subsequent postganglionic adrenoceptor activation and ultimately reduces arteriolar vasoconstriction. See the DrugBank link for further details.
External links