Ligand id: 7200

Name: ibutilide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 78.02
Molecular weight 384.24
XLogP 4.82
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to correct atrial fibrillation and atrial flutter.
Mechanism Of Action and Pharmacodynamic Effects
The primary mechanism of action of ibutilide is to block potassium voltage-gated channel subfamily H member 2 (KCNH2, aka hERG), a potassium channel α subunit responsible for controlling the cardiac action potential. The drug may also have effects on other ion channels. See the DrugBank link for further details.
External links