indapamide

Ligand id: 7203

Name: indapamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 100.88
Molecular weight 365.06
XLogP 2.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat oedema and hypertension.
Mechanism Of Action and Pharmacodynamic Effects
The drug's molecular mechanism of action is complex, and may include inhibition of the thiazide-sensitive sodium-chloride cotransporter, SLC12A3, antagonism of the voltage gated potassium channels, KCNQ1 and KCNE1, and increased synthesis of PGE2 (prostaglandin with vasodilatory action). See the DrugBank link for further details.
External links