Ligand id: 7204

Name: isocarboxazid

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View more information in the IUPHAR Pharmacology Education Project: isocarboxazid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 67.16
Molecular weight 231.1
XLogP 3.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat anxiety, panic, or phobias associated with depression.
Mechanism Of Action and Pharmacodynamic Effects
By inhibiting monoamine oxidase (MAO), this drug increases the levels of serotonin and catecholamine neurotransmitters (epinephrine, norepinephrine, and dopamine) in synaptic storage granules throughout the central and sympathetic nervous systems. This general increase in monoamine neurotransmitters is resposible for the drug's antidepressant action. See the DrugBank link for further details.
External links