lisdexamfetamine

Ligand id: 7213

Name: lisdexamfetamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 84.63
Molecular weight 263.2
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Lisdexamfetamine is used to treat attention deficit hyperactivity disorder (ADHD) in combination with educational and psychosocial intervention. In February 2015, the US FDA expanded approval to include the treatment of binge-eating disorder.
Mechanism Of Action and Pharmacodynamic Effects
This drug blocks the reuptake of norepinephrine and dopamine into presynaptic neurons, resulting in increased levels of monoamines active in the extraneuronal space. As these neurotransmitters are involved in maintaining alertness and sustaining thought and motivation this action may underlie the clinical benefits in ADHD. However the full molecular mechanism of action remains to be fully resolved. See the DrugBank link for further details.
External links