loperamide

Ligand id: 7215

Name: loperamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 43.78
Molecular weight 476.22
XLogP 8.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat diarrhea.
Mechanism Of Action and Pharmacodynamic Effects
This drug slows peristalsis, allowing the gut to re-absorb more fluid and nutrients. This is achieved through calcium channel block and activation of μ opioid receptors. As this reduces the overall stool mass produced the drug is used for this effect in patients with ileostomy.
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