Ligand id: 7221

Name: pethidine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pethidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 29.54
Molecular weight 247.16
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat moderate to severe pain caused by disease, trauma, surgery or childbirth.
Mechanism Of Action and Pharmacodynamic Effects
As an opioid receptor agonist, meperidine inhibits release of nociceptive neurotransmitters, vasopressin and somatostatin. In addition opioid receptor activation alters potassium and calcium channel activity, leading to hyperpolarization and reduced neuronal excitability typical of analgesia.
External links