mephenytoin

Ligand id: 7223

Name: mephenytoin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 52.9
Molecular weight 218.11
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat seizures in patients in whom other drugs have failed. However, this drug is no longer commercially available in the US or the UK. Other national approval agencies may continue granting marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
This drug’s molecular mechanism of action has not been fully resolved, but appears to involve inhibition of the repetitive firing of action potentials observed during seizure activity. This may be due to inhibition of neuronal sodium channels. CHEMBL lists sodium channel alpha subunits as this drug's molecular targets. The genes and proteins for SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section. See the DrugBank link for further details.