mepivacaine

Ligand id: 7224

Name: mepivacaine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 35.83
Molecular weight 246.17
XLogP 3.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mepivacaine is used as a local anaesthetic for dental procedures and for surgery carried out under epidural or spinal block.
Mechanism Of Action and Pharmacodynamic Effects
The molecular mechanism of action of this drug may be due to inhibition of neuronal sodium channels, which blocks action potentials and subsequent nerve impulses. CHEMBL lists sodium channel alpha subunits as this drug's molecular targets. The genes and proteins for SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section. See the DrugBank link for further details.