meprobamate

Ligand id: 7225

Name: meprobamate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 106.62
Molecular weight 218.13
XLogP 2.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Meprobamate is anxiolytic drug used to treat the symptoms of anxiety and related conditions. However, in 2012 the European Medicines Agency recommended withdrawal of all EU marketing authorisations for meprobamate containing drugs, due to severe adverse effects.
Mechanism Of Action and Pharmacodynamic Effects
Meprobamate can positively modulate the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic and sedative actions and may also contribute towards the suggested anticonvulsant and skeletal muscle relaxant actions of the drug.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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