methohexital

Ligand id: 7233

Name: methohexital

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 69.97
Molecular weight 262.13
XLogP 2.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to induce anesthesia.
Mechanism Of Action and Pharmacodynamic Effects
Methohexital binds to a distinct site within Cl ionophore of GABAA ion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.