Ligand id: 7235

Name: methyclothiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 126.33
Molecular weight 358.96
XLogP -0.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Methyclothiazide is used to treat hypertension and to reduce oedema assiociated with conditions such as congestive heart failure, liver cirrhosis, and kidney failure or steroid-induced oedema.
Mechanism Of Action and Pharmacodynamic Effects
Reduces water retention by inhibiting Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys by inhibiting the Na-Cl symporter SLC12A3. See the DrugBank link for further details.