metipranolol

Ligand id: 7239

Name: metipranolol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.79
Molecular weight 309.19
XLogP 2.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and glaucoma.
Mechanism Of Action and Pharmacodynamic Effects
The active metabolite, desacetylmetipranolol, is likely to be the antagonist of the β1- and β2-adrenoceptors, as metipranolol itself has little intrinsic sympathomimetic or direct myocardial depressant action. Antagonism of β-adrenoceptors prevents the receptors from processing signals from endogenous epinephrine and norepinephrine, resulting in decreased force of heart contractions and lowered heart rate. As an anti-glaucoma agent the drug (or its active metabolite) reduces aqueous humor production. See the DrugBank link for further details.
External links