Ligand id: 7241

Name: mirtazapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 19.37
Molecular weight 265.16
XLogP 3.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mirtazapine is used to treat major depressive disorder. There is some clinical support for improved clinical effectiveness, in therapies combining dissimilar antidepressants for the treatment of severe depression [4]. For example, combining mirtazapine with a selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI). Evidence for and against this type of combination therapy is reviewed by Thase (2013) [5].
Mechanism Of Action and Pharmacodynamic Effects
Mirtazapine is a centrally acting α2-adrenoceptor antagonist which increases norepinephrine and serotonin release. The increased levels of these neurotransmitters contributes to the drug's anxiolytic effect.
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