Ligand id: 7244

Name: moracizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 99.9
Molecular weight 427.16
XLogP 3.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Moracizine is used to treat severe cardiac arrhythmias. However, this drug has been withdrawn from use in the US, but other national approval agencies may continue to grant marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
This drug stabilises the cardiac membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. ChEMBL report that this drug acts by blocking sodium channel α subunits. The genes and proteins SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section. In vitro guinea-pig studies are reported in [1].
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