Ligand id: 7251

Name: orphenadrine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 12.47
Molecular weight 269.18
XLogP 6.05
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat pain, especially musculoskeletal pain (as the citrate salt). Also used to treat all forms of Parkinsonism (as the hydrochloride salt).
Mechanism Of Action and Pharmacodynamic Effects
Orphenadrine has central anticholinergic action and low level antihistamine action. Due to the polypharmacology of this drug we have not mapped it to a primary target.
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