oxcarbazepine

Ligand id: 7254

Name: oxcarbazepine

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View more information in the IUPHAR Pharmacology Education Project: oxcarbazepine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 64.39
Molecular weight 252.09
XLogP 4.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used primarily to treat epileptic seizures, but in countries other than the US may be used to treat bipolar disorder.
Mechanism Of Action and Pharmacodynamic Effects
The pharmacological activity of oxcarbazepine is thought to be associated with its 10-monohydroxy metabolite (MHD), which acts as a sodium channel inhibitor. This blocks initiation and conductance of nerve impulses. The genes and proteins SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section.
External links