pamidronic acid

Ligand id: 7259

Name: pamidronic acid

Abbreviated name: disodium pamidronate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 6
Rotatable bonds 4
Topological polar surface area 180.93
Molecular weight 235
XLogP -4.66
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat cancer-related hypercalcemia.
Mechanism Of Action and Pharmacodynamic Effects
By shifting the equilibrium of bone resorption/formation towards the formation side by various potential mechanisms, drug treatment makes bone stronger. ChEMBL list the molecular target of action of this drug as farnesyl pyrophosphate synthase (FDPS) which links with the drugs ability to inhibit osteoclast activity.
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