penbutolol

Ligand id: 7263

Name: penbutolol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 41.49
Molecular weight 291.22
XLogP 4.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Penbutolol antagonises the effects of endogenous epinephrine and norepinephrine at β1-adrenoceptors in cardiac and vascular smooth muscle cells. This decreases heart rate, cardiac output, and blood pressure. See the DrugBank link for further details.
External links