phenelzine

Ligand id: 7266

Name: phenelzine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 38.05
Molecular weight 136.1
XLogP 2.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat depression.
Mechanism Of Action and Pharmacodynamic Effects
MAOIs increase presynaptic levels of monoamines by inhibiting their catabolism after presynaptic reuptake. Therefore, inhibiting MAOs, increases the levels of serotonin and catecholamine neurotransmitters (epinephrine, norepinephrine, and dopamine) in neurones of the central and sympathetic nervous systems. This action appears to restore the relative deficiencies of catecholamines or suppressed serotonin/norepinephrine signalling postulated to be causative in depressive conditions.
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