Ligand id: 7269

Name: phentermine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 26.02
Molecular weight 149.12
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an appetite suppressant to aid weight loss in programmes which include diet and exercise. This drug is not approved for use in the EU.
Mechanism Of Action and Pharmacodynamic Effects
The main action of this drug is to inhibit noepinephrine reuptake by the transporter SLC6A2. The resulting increase in free noepinephrine appears to suppress appetite and hunger signals. The drug may have other mechanistic actions. See the DrugBank link for further details.
External links