pipobroman

Ligand id: 7271

Name: pipobroman

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 40.62
Molecular weight 353.96
XLogP 1.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an antineoplastic agent. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. According to the US FDA International Drug Names listing, this drug is only available in France and Italy.
Mechanism Of Action and Pharmacodynamic Effects
As a DNA alkylating (cross-linking) agent, pipobroman treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.