Ligand id: 7272

Name: pirbuterol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 85.61
Molecular weight 240.15
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to relieve asthmatic bronchospasm.
Mechanism Of Action and Pharmacodynamic Effects
Pirbuterol is an agonist of β2-adrenoceptors. Activation of these receptors increases cAMP levels which causes downstream relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells such as mast cells.
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