proparacaine

Ligand id: 7283

Name: proparacaine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 64.79
Molecular weight 294.19
XLogP 2.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is often used in eye drops to anaesthetise the eye for invasive procedures.
Mechanism Of Action and Pharmacodynamic Effects
The likely molecular mechanism of action (MMOA) of this drug is inhibition of voltage-gated sodium channels on neuronal membranes. This prevents action potential and nerve signal propagation and transmission. The genes and proteins SNC1A-SNC11A are listed in this database in the voltage-gated sodium channels section.
External links