pseudoephedrine

Ligand id: 7286

Name: pseudoephedrine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 32.26
Molecular weight 165.12
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as a nasal/sinus decongestant.
Mechanism Of Action and Pharmacodynamic Effects
Pseudoephedrine is an agonist of α- and β-adrenoceptors. Activation of α-adrenoceptors in the nasal mucosa, causes vasoconstriction and reduces congestion. Activation of β-adrenoceptors relaxes bronchial smooth muscle. Pseudoephedrine also acts at the norephinephrine transporter, SLC6A2, promoting release of stored norephinephrine into the neuronal synapse, leading to activation of postsynaptic adrenoceptors in addition to the direct, drug-induced activation.
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