Ligand id: 7296

Name: sevoflurane

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 9.23
Molecular weight 200.01
XLogP 3.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for induction and maintenance of general anaesthesia
Mechanism Of Action and Pharmacodynamic Effects
Sevoflurane depresses activity in the central nervous system (this includes muscle relaxation and reduced sensitivity to pain) leading to loss of consciousness. The drug decreases cell-cell signalling across gap junctions by modulating the activity of a range of ion channels that underlie the action potential, thereby altering tissue excitability.
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