Ligand id: 7297

Name: sotalol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 86.81
Molecular weight 272.12
XLogP 1.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat cardiac arrythymias.
In October 2014, Solytize® became the first oral preparation containing sotalol hydrochloride to gain approval for the treatment of life-threatening ventricular arrhythmias (US FDA approval).
Mechanism Of Action and Pharmacodynamic Effects
This drug antagonises cardiac β-adrenoceptors. It also blocks inward potassium channel currents, prolonging repolarisation and slowing conduction at the atrioventricular (AV) node. See the DrugBank link for further details.
External links