temazepam

Ligand id: 7300

Name: temazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 52.9
Molecular weight 300.07
XLogP 3.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat insomnia. In addition, temazepam may be used as a pre-operative sedative (anxiolytic action).
Mechanism Of Action and Pharmacodynamic Effects
Temazepam positively modulates the activity of GABAA anion channels. The drug increases inhibitory GABAergic tone and causes neuro-inhibition. Drug-induced effects are observed clinically as anxiolytic, sedative, anticonvulsant and skeletal muscle relaxant actions.
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