Ligand id: 7304

Name: thiabendazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 69.81
Molecular weight 201.04
XLogP 2.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Originally approved as a treatment for nematode infestation, thiabendazole has been used off-label as a chelating agent to treat metal poisoning. This drug may also have anti-angiogenic actions [1], with potential to be repurposed as an anti-tumor therapy.
Mechanism Of Action and Pharmacodynamic Effects
The drug binds metals such as lead, mercury or antimony and facilitates their excretion.
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