tocainide

Ligand id: 7309

Name: tocainide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 58.61
Molecular weight 192.13
XLogP 2.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tocainide is used to treat serious cardiac arrhythmias. Use has been discontinued in the US, but other national approval agencies may continue marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
This drug stabilises the cardiac membrane by binding to sodium channels, and decreasing permeability to Na+ ions. This blocks initiation and conductance of nerve impulses. ChEMBL report that this drug acts by blocking sodium channel α subunits (genes SNC1A-SNC11A) are listed in this database in the Voltage-gated sodium channels section.