Ligand id: 7312

Name: torsemide

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View more information in the IUPHAR Pharmacology Education Project: torasemide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 111.53
Molecular weight 348.13
XLogP 3.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and oedema associated with congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Torsemide inhibits ion transport via the kidney-specific Na-K-Cl symporter SLC12A1. These transporters are located in the ascending loop of Henle and their inhibition results in increased water excretion.
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