trichlormethiazide

Ligand id: 7314

Name: trichlormethiazide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 135.12
Molecular weight 378.9
XLogP -0.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and oedema (associated with heart failure, hepatic cirrhosis and corticosteroid therapy). Use of this drug appears to have been discontinued in the US, but other national approval agencies may continue marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Trichlormethiazide blocks the active reabsorption of chloride in the ascending loop of Henle by inhibiting the thiazide-sensitive sodium-chloride symporter, SLC12A3. This results in excretion of sodium, chloride and water, thus reducing fluid retention and oedema.