Ligand id: 7350

Name: eslicarbazepine

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View more information in the IUPHAR Pharmacology Education Project: eslicarbazepine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 66.56
Molecular weight 254.11
XLogP 2.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The acetate form is a prodrug for eslicarbazepine, and has had European (EMA) approval from 2009 (as Zebinix®), as adjunctive therapy for partial-onset epileptic seizures. In September 2015, the US FDA approved eslicarbazepine as a monotherapy for partial-onset seizures.
Mechanism Of Action and Pharmacodynamic Effects
This drug has identical action to oxcarbazepine. The pharmacological activity of oxcarbazepine is thought to be associated with its 10-monohydroxy metabolite (MHD), which acts as a sodium channel inhibitor. This blocks initiation and conductance of nerve impulses. The genes and proteins SNC1A-SNC11A are listed in this database in the Voltage-gated sodium channels section.
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