Ligand id: 7352

Name: macitentan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 136.6
Molecular weight 585.96
XLogP 3.23
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Macitentan is approved for the treatment of pulmonary arterial hypertension (PAH).
Mechanism Of Action and Pharmacodynamic Effects
Macitentan is an endothelin receptor antagonist. It blocks endothelin-1-induced activation of endothelin A and B receptors (ETA and ETB respectively) located on blood vessels and smooth muscle, and reduces fibrosis and vasoconstriction by modulating the renin-angiotensin system.
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