umeclidinium

Ligand id: 7354

Name: umeclidinium

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 29.46
Molecular weight 428.26
XLogP 8.59
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Umeclidinium is an anticholinergic drug, used in combination with vilanterol as a combined single medication (marketed as Anoro Ellipta®) indicated for the treatment of chronic obstructive pulmonary disease (COPD) [1]. Umeclidinium is also available in a single agent medication called Incruse Ellipta®.
Mechanism Of Action and Pharmacodynamic Effects
Umeclidinium is an antagonist of the muscarinic acetylcholine receptors. The drug acts on muscarinic acetylcholine receptors in lung tissue, blocking the effect of endogenous acetylcholine, and reducing parasympathetic contraction of airway smooth muscle. This action helps patients to breath more easily.
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